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You may report side effects to FDA at 1-800-FDA-1088 hair loss. The most common side effects of Lotrisone cream include burning, tingling, rash, swelling, and infections. Do not use more than 45 grams of the cream or 45 milliliters of the lotion per week unless directed and closely monitored by your doctor. Find patient medical information for Lotrisone topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings WebMD provides common contraindications for Lotrisone Cream. Hyperesthesia, an increased nerve sensitivity WebMD provides common contraindications for Lotrisone Cream. Skin irritation or rash around the mouth or lips. This is not a complete list of side effects and others may occur. Irritation where Lotrisone (betamethasone and clotrimazole cream) is used. Severe dizziness, vomiting, nausea. 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The doctor has mentioned none of these when he perscribed and I am really upset about this Lotrisone cream contains a combination of betamethasone and clotrimazol. High doses or long-term use of Lotrisone cream can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. You may report side effects to FDA at 1-800-FDA-1088. However, many people have no side effects or only have minor side effects There are possibilities for the steroid cream to be absorbed by your skin that might go on to affect adrenal gland. These are not all the possible side effects of Lotrisone cream. Lotrisone cream has two main combinations of clortrimazol and betamethasone. 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